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The identification of novel risk genetic/molecular biomarkers in the prediction of patients with cardiovascular diseases for management of the patients

Cardiovascular disease (CAD) is the leading cause of death worldwide as well as in Iran. Several factors have been documented to be associated with the risk of this disease including genetics and molecular background of patients. The aim of current study is to explore and identify novel genetics biomarkers in CAD patients of our cohort. In the present study, we will use the patients of our hospitals (Ghaem and Reza hospitals) from MASHAD cohort (including around 9700 patients) in order to investigate our hypothesis to propose innovative novel risk biomarkers in CAD patients, which might be used for clinical management of patients. For this, we will do a systematic review and meta-analysis on the potential locus recognized by genome wild association studies. Then, we will genotypes our patients and evaluate the impact of those genotypes of each gene with demographic and clinical characteristics of population using univariate and multivariate analysis. we will also employ data mining and artificial neural network analysis on the clinical characteristics of population and genetic/molecular background of patients in order to identify new potential biomarkers associated with increased/decreased risk of CAD and a new formula for clinical management of patients with cardiovascular disease.
To get more insight about this project, please contact the group leader of this project and get more information from our previous recent publications
Ghayour-Mobarhan M, et al. Mashhad stroke and heart atherosclerotic disorder (MASHAD) study: design, baseline characteristics and 10-year cardiovascular risk estimation. Int J Public Health. 2015 Jul;60(5):561-72
Oladi M, Nohtani M, Avan A, et al., Impact of the C1431T Polymorphism of the Peroxisome Proliferator Activated Receptor-Gamma (PPAR-γ) Gene on Fasted Serum Lipid Levels in Patients with Coronary Artery Disease.Ann Nutr Metab. 2015;66(2-3):149-54
Mirhafez SR, …, Ghayour-Mobarhan M. Relationship between serum cytokine and growth factor concentrations and coronary artery disease. Clin Biochem. 2015 Jun;48(9):575-80
Parizadeh SA, …. Ghayour-Mobarhan M. Lack of an association between a functional polymorphism in the neuropeptide Y gene promoter and the presence of coronary artery disease in an Iranian population. Ann Nutr Metab. 2014;65(4):333-40.
Dr. Ghyour
Dr. Avan
Dr. Pasdar
Dr. Meshkat

The current program will be run, as described above, together with some related courses, including Molecular Medical Genetics, Molecular Epidemiology, Molecular biology techniques and Bioinformatics

Basic Information:
Program Type: Degree Based
Level Of study: Fellowship
School / Faculty: Medicine
Department: New Sciences and Technologies
Major (Name Of Program): Molecular Medicine
This program contact information:
Telephone: +98 51 38002289
Fax: +98 51 38002287
Mobile: 00989155171478
Email Address:
Address: Department of New Sciences and Technologies. Mashhad University of Medical Sciences.
Contact Person Name: Dr. M Ghayour Mobarhan, Dr. A Avan Dr. AP Pasd
Program Detail:
Length of Training:

18 months

Language Requirement:


Admission Requirement:

MSc or PhD degree in biomedical/biomolecular sciences

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