Musculoskeletal disorders can have a major effect on functional mobility, medical costs, and quality of life of patients suffering from a broad spectrum of orthopedic conditions. Low back pain, cervical joint dysfunctions, shoulder disorders and knee injuries are the most common musculoskeletal complaints observed in physiotherapy clinics. Recently, diagnosis and treatment based on the movement system impairments constitute a fundamental role in management of patients seeking physiotherapy services and those who discover prevention of recurrency and chronicity in these common disorders. Moreover, based on the Sullivan’s approach, intervention based on four stages of motor control, i.e. mobility, stability, controlled mobility, and skill would help the patients for symptom reduction, joint stability, return to activity level before injury, and safe participation in social roles, respectively. Therefore, in the first section of this short course, we will educate the participants how to diagnose different movement impairments in different regions of the musculoskeltal systems. In the second section, we will practice the appropriate mobilization, manipulation, and muscle energy techniques that should be implemented for improving the mobility in specific movement impairment syndromes. Also, the appropriate stabilization and coordination exercises that should be prescribed for safe return to pre-injury daily and sports activities will be provided. Finally, we will practice this method of evaluation and treatment on different patients as case reports and evaluate the outcomes post-intervention.